Frederico

VAR2 Pharmaceuticals attending 15th World ADC London

Our CEO and founder Ali Salanti will be delivering an invited talk alongside other European and global leaders innovating in the antibody drug conjugate (ADC) space at the 15th World ADC London conference, scheduled to take place in London between March 3rd and 6th . Ali will share with the audience our recent progress in […]

First patient enrolled in the VAR2 Pharma – TRACER Phase 0 oncology trial

GRONINGEN, NETHERLANDS (21 January 2025) – TRACER and VAR2 Pharma announce the first patient enrolled in the VARTUTRACE study, a Phase 0 first-in-human imaging trial (NCT06645808). The patient, suffering from lung carcinoma received the Investigational Medicinal Product (IMP), a zirconium-89-labeled single-chain variable fragment (scFv), Vartumab, on Dec 17, 2024. The patient successfully completed all study […]

VAR2 Pharmaceuticals receives approval for first-in-human PET/CT imaging study with Vartumabs

GRONINGEN, NETHERLANDS (30 September 2024) – VAR2 Pharmaceuticals ApS (‘VAR2 Pharma’) has received regulatory approval for their first-in-human Phase 0 clinical trial. In this study, the safety, tolerability, and biodistribution of two zirconium-89 labeled single-chain variable Fragments (scFvs) will be evaluated using PET/CT molecular imaging. The Danish company VAR2 Pharma is collaborating with TRACER, a […]

New publication in Nature Communications on the development of VAR2 Pharma’s first-in-class antibodies – Vartumabs – and their pre-clinical validation as a platform for cancer therapeutics

The development of cancer is accompanied by a change in the composition of a sugar molecule called chondroitin sulfate. This sugar molecule becomes unusually long and heavily sulfated. For years, VAR2 has pursued the development of cancer therapeutics targeting this secondary modification called oncofetal chondroitin sulfate. But until recently, the known difficulties in generating antibodies […]

New publication in Cell Reports Medicine uses recombinant VAR2CSA to isolate circulating tumor cells and generate patient-relevant mouse models for pancreatic cancer

The development of CTC-derived models specific to PDAC has remained challenging due to the limited number of CTCs retrieved from patients’ samples.   In work led by our collaborators, we demonstrated that our proprietary recombinant VAR2CSA, which specifically binds oncofetal chondroitin sulfate, retrieved more live CTCs than single antibodies for traditional CTC biomarkers (EpCAM, CD7, […]