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Publications
2024
Khazamipour et. al. Transient CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors. BioRxiv
Vidal-Calvo et al. Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate. Nature Communications
2023
Skeltved et al. Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice. Exp Clin Cancer Res
Pihl et al. Malaria Biomimetic for Tumor Targeted Drug Delivery. ACS Nano
2022
Al-Nakouzi et al. Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer. Nature Communications
Wang et al. Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells. Scientific Reports
2021
Zarni et. al. Oncofetal Chondroitin Sulfate Is a Highly Expressed Therapeutic Target in Non-Small Cell Lung Cancer. Cancers
Raskov et al. Natural Killer Cells in Cancer and Cancer Immunotherapy. Cancer Letters
Spliid et al. The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility. J Biol Chem
Wang et al. Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding. Nature Communications
Nordmaj et al. Development of a bispecific immune engager using a recombinant malaria protein. Cell Death Disease
2020
Sand et al. Optimization of rVAR2-Based Isolation of Cancer Cells in Blood for Building a Robust Assay for Clinical Detection of Circulating Tumor Cells. Int. J. Mol. Sci.
Ahrens et al. The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis. Front Cell Dev Biol.
Clausen et al. A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine. Cell Death Discovery
Toledo et al. An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer. Glycobiology
2019
Bang-Christensen et al. Capture and detection of circulating glioma cells using the recombinant VAR2CSA malaria protein. Cells
Agerbæk et al. The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner. Nature Communications
2018
Chen et al. The GAGOme: a cell-based library of displayed glycosaminoglycans. Nature Methods
2017
Seiler et al. An oncofetal glycosaminoglycan modification provides therapeutic access to cisplatin-resistant bladder cancer. Eur Urol
Agerbæk et al. Burkitt lymphoma express oncofetal Chondroitin Sulfate without being a reservoir for placental malaria sequestration. Int J Cancer
2016
Clausen et al. Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility. Mol Cancer Res
Ayres Pereira et al. Placental sequestration of Plasmodium falciparum malaria parasites is mediated by the interaction between VAR2CSA and chondroitin sulfate A on syndecan-1. PLoS Pathogens
Sugiura et al. Molecular dissection of placental malaria protein VAR2CSA interaction with a chemo-enzymatically synthesized chondroitin sulfate library. Glycoconj J
2015
Salanti et al. Targeting human cancer by a glycosaminoglycan binding malaria protein. Cancer Cell
2012
Clausen et al. Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria. J Biol Chem